Since 1958, Project HOPE (Health Opportunities for People Everywhere) has worked to make health care available for people around the globe. Project HOPE is committed to long-term sustainable health care. Work includes educating health professionals and community health workers, strengthening health systems, fighting diseases such as TB, HIV/AIDS and diabetes and providing humanitarian assistance through donated medicines, medical supplies and volunteer medical help.

Project HOPE's most visible aspect was the SS HOPE, the first peacetime hospital ship. The SS HOPE was retired in 1974, after sailing to Indonesia, South Vietnam, Peru, Ecuador, Guinea, Nicaragua, Colombia, Ceylon (Sri Lanka), Tunisia, Jamaica, and Brazil. On these voyages doctors, nurses, and technical staff provided medical care and training to people in each country visited. The SS HOPE was not replaced, and emphasis switched entirely to land-based operations.